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PhAcA-TBOA
MW:
378.42
logP:
0.83
H-acceptors:
6
H-donors:
4
Rotatable bonds:
7
EAATs:
 
EAAT1:
0.143 µM
EAAT2:
0.529 µM
EAAT3:
 
EAAT4:
 
EAAT5:
 
Cell line:
Method: Radioactive labelling
Substrate: n/a
Comment: The radioactive label was 14C-glutamate. The uptake assays were performed in MDCK cells stably expressing EAAT2 or EAAT3.
CNB-TBOA
MW:
383.35
logP:
0.6
H-acceptors:
7
H-donors:
4
Rotatable bonds:
6
EAATs:
 
EAAT1:
0.286 µM
EAAT2:
0.105 µM
EAAT3:
5.3 µM
EAAT4:
 
EAAT5:
 
Cell line:
Method: Radioactive labelling
Substrate: n/a
Comment: The radioactive ligand was 14C-glutamate.
The experiments were performed on COS-1 cells transiently expressing EAAT1- EAAT3.
PMB-TBOA
MW:
388.37
logP:
0.44
H-acceptors:
6
H-donors:
4
Rotatable bonds:
6
EAATs:
 
EAAT1:
0.116 µM
EAAT2:
0.059 µM
EAAT3:
2.4 µM
EAAT4:
 
EAAT5:
 
Cell line:
Method: Radioactive labelling
Substrate: n/a
Comment: The radioactive label was 14C-glutamate. The assays were performed in COS-1 cells transiently expressing EAAT1-3.
cHexcA-TBOA
MW:
364.39
logP:
0.65
H-acceptors:
6
H-donors:
4
Rotatable bonds:
5
EAATs:
 
EAAT1:
 
EAAT2:
244 µM
EAAT3:
288 µM
EAAT4:
 
EAAT5:
 
Cell line:
Method: Radioactive labelling
Substrate: n/a
Comment: The radioactive label was 14C-glutamate. The uptake assays were performed in MDCK cells stably expressing EAAT2 or EAAT3.
PrA-TBOA
MW:
310.3
logP:
-0.67
H-acceptors:
6
H-donors:
4
Rotatable bonds:
5
EAATs:
 
EAAT1:
 
EAAT2:
1.2 µM
EAAT3:
4.1 µM
EAAT4:
 
EAAT5:
 
Cell line:
Method: Radioactive labelling
Substrate: n/a
Comment: The radioactive label was 14C-glutamate. The uptake assays were performed in MDCK cells stably expressing EAAT2 or EAAT3.
PivA-TBOA
MW:
338.36
logP:
0.6
H-acceptors:
4
H-donors:
6
Rotatable bonds:
5
EAATs:
 
EAAT1:
44 µM
EAAT2:
1 µM
EAAT3:
23 µM
EAAT4:
 
EAAT5:
 
Cell line:
Method: Radioactive labelling
Substrate: n/a
Comment: The radioactive label was 14C-glutamate. The uptake assays were performed in MDCK cells stably expressing EAAT2 or EAAT3.
PivA-TBOA
MW:
338.36
logP:
0.6
H-acceptors:
4
H-donors:
6
Rotatable bonds:
5
EAATs:
 
EAAT1:
 
EAAT2:
0.98 µM
EAAT3:
3.5 µM
EAAT4:
 
EAAT5:
 
Cell line:
Method: Radioactive labelling
Substrate: n/a
Comment: The radioactive label was 14C-glutamate. The uptake assays were performed in MDCK cells stably expressing EAAT2 or EAAT3.
3,4-diMeO-BzA-TBOA
MW:
418.47
logP:
0.32
H-acceptors:
8
H-donors:
4
Rotatable bonds:
4
EAATs:
 
EAAT1:
 
EAAT2:
49 µM
EAAT3:
917 µM
EAAT4:
 
EAAT5:
 
Cell line:
Method: Radioactive labelling
Substrate: n/a
Comment: The radioactive label was 14C-glutamate. The uptake assays were performed in MDCK cells stably expressing EAAT2 or EAAT3.
t-Bu-BzA-TBOA
MW:
414.45
logP:
2.27
H-acceptors:
6
H-donors:
4
Rotatable bonds:
4
EAATs:
 
EAAT1:
 
EAAT2:
0.025 µM
EAAT3:
0.182 µM
EAAT4:
 
EAAT5:
 
Cell line:
Method: Radioactive labelling
Substrate: n/a
Comment: The radioactive label was 14C-glutamate. The uptake assays were performed in MDCK cells stably expressing EAAT2 or EAAT3.
F-BzA-TBOA
MW:
376.34
logP:
0.73
H-acceptors:
7
H-donors:
4
Rotatable bonds:
4
EAATs:
 
EAAT1:
 
EAAT2:
0.022 µM
EAAT3:
0.473 µM
EAAT4:
 
EAAT5:
 
Cell line:
Method: Radioactive labelling
Substrate: n/a
Comment: The radioactive label was 14C-glutamate. The uptake assays were performed in MDCK cells stably expressing EAAT2 or EAAT3.