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1-aminocyclobutane-1,3-dicarboxylic acid
MW:
159.14
logP:
-3.356
H-acceptors:
5
H-donors:
3
Rotatable bonds:
2
EAATs:
30 µM
EAAT1:
 
EAAT2:
 
EAAT3:
 
EAAT4:
 
EAAT5:
 
Brain region: rat forebrain
Method: Radioactive labelling
Substrate: yes
Comment: The radioactive substrate was 3H-aspartate.
The synaptosomal preparation used exhibited the greatest correspondance with EAAT2.
SNAP-5114
MW:
415.52
logP:
5.18
H-acceptors:
3
H-donors:
1
Rotatable bonds:
7
GATs:
 
GAT1:
 
GAT2:
140 µM
GAT3:
21 µM
GAT4:
 
SKF 89976A
MW:
335.439
logP:
4.447
H-acceptors:
3
H-donors:
1
Rotatable bonds:
6
GATs:
 
GAT1:
0.64 µM
GAT2:
7210 µM
GAT3:
550 µM
GAT4:
4390 µM
Tiagabine
MW:
375.55
logP:
3.417
H-acceptors:
3
H-donors:
1
Rotatable bonds:
6
GATs:
 
GAT1:
0.67 µM
GAT2:
1670 µM
GAT3:
1410 µM
GAT4:
2040 µM
CI-966
MW:
509.869
logP:
6.459
H-acceptors:
10
H-donors:
2
Rotatable bonds:
7
GATs:
 
GAT1:
1.2 µM
GAT2:
300 µM
GAT3:
297 µM
GAT4:
1140 µM
Taurine
MW:
125.148
logP:
-1.02
H-acceptors:
4
H-donors:
2
Rotatable bonds:
2
GATs:
 
GAT1:
32300 µM
GAT2:
13200 µM
GAT3:
1270 µM
GAT4:
2860 µM
DABA
MW:
118.134
logP:
-3.826
H-acceptors:
4
H-donors:
3
Rotatable bonds:
3
GATs:
 
GAT1:
128 µM
GAT2:
528 µM
GAT3:
300 µM
GAT4:
710 µM
beta-alanine
MW:
89.0932
logP:
-0.444
H-acceptors:
3
H-donors:
2
Rotatable bonds:
2
GATs:
 
GAT1:
2920 µM
GAT2:
1100 µM
GAT3:
66 µM
GAT4:
110 µM
Hypotaurine
MW:
109.149
logP:
-1.674
H-acceptors:
3
H-donors:
2
Rotatable bonds:
2
GATs:
 
GAT1:
1010 µM
GAT2:
536 µM
GAT3:
52 µM
GAT4:
73 µM
NNC-711
MW:
386.872
logP:
3.69
H-acceptors:
5
H-donors:
2
Rotatable bonds:
7
GATs:
 
GAT1:
0.38 µM
GAT2:
3570 µM
GAT3:
729 µM
GAT4:
349 µM