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L-trans-2,3-PDC
MW:
159.14
logP:
-1.1
H-acceptors:
4
H-donors:
3
Rotatable bonds:
2
EAATs:
33.6 µM
EAAT1:
 
EAAT2:
 
EAAT3:
 
EAAT4:
 
EAAT5:
 
Brain region: cortex
Method: Radioactive labelling
Substrate: no
Comment: Radiactive ligand:3H-aspartate.
The synaptosomal preparation used exhibited the greatest correspondance with EAAT2.
(2S,4S)-pyrrolidine-2,4-dicarboxylic acid
MW:
159.14
logP:
-1.1
H-acceptors:
4
H-donors:
3
Rotatable bonds:
2
EAATs:
66 µM
EAAT1:
 
EAAT2:
 
EAAT3:
 
EAAT4:
 
EAAT5:
 
Brain region: cortex
Method: Radioactive labelling
Substrate: yes
Comment: The radioactive ligand was 3H-aspartate.
The synaptosomal preparation used exhibited the greatest correspondance with EAAT2.
(2S)-t-PDC
MW:
159.14
logP:
-0.84
H-acceptors:
4
H-donors:
3
Rotatable bonds:
2
EAATs:
1.5 µM
EAAT1:
 
EAAT2:
 
EAAT3:
 
EAAT4:
 
EAAT5:
 
Brain region: cortex
Method: Radioactive labelling
Substrate: yes
Comment: The radioactive substrate was 3H-aspartate.
The synaptosomal preparation used exhibited the greatest correspondance with EAAT2.
(1r,4r)-2-aza-bicyclo(2.1.1)hexane-1,4-dicarboxylic acid
MW:
171.15
logP:
-0.84
H-acceptors:
4
H-donors:
3
Rotatable bonds:
2
EAATs:
6.8 µM
EAAT1:
 
EAAT2:
 
EAAT3:
 
EAAT4:
 
EAAT5:
 
Brain region: cortex
Method: Radioactive labelling
Substrate: yes
Comment: The radioactive ligand was 3H-aspartate.
The synaptosomal preparation used exhibited the greatest correspondance with EAAT2.
L-anti-endo-MPDC
MW:
171.15
logP:
-1.35
H-acceptors:
4
H-donors:
3
Rotatable bonds:
2
EAATs:
4.9 µM
EAAT1:
 
EAAT2:
 
EAAT3:
 
EAAT4:
 
EAAT5:
 
Brain region: cortex
Method: Radioactive labelling
Substrate: yes
Comment: The radioactive ligand was 3H-aspartate.
The synaptosomal preparation used exhibited the greatest correspondance with EAAT2.
3-Hydroxyasprtic acid
MW:
149.102
logP:
-4.061
H-acceptors:
6
H-donors:
4
Rotatable bonds:
3
EAATs:
 
EAAT1:
 
EAAT2:
 
EAAT3:
 
EAAT4:
0.6 µM
EAAT5:
2.5 µM
2-amino-4-methyl-glutaric acid
MW:
161.156
logP:
-2.957
H-acceptors:
5
H-donors:
3
Rotatable bonds:
4
EAATs:
 
EAAT1:
1600 µM
EAAT2:
89.9 µM
EAAT3:
1.08 µM
EAAT4:
109 µM
EAAT5:
 
D-Aspartate
MW:
133.103
logP:
-3.236
H-acceptors:
5
H-donors:
3
Rotatable bonds:
3
EAATs:
9 µM
EAAT1:
 
EAAT2:
 
EAAT3:
 
EAAT4:
 
EAAT5:
 
2-amino-3-sulfo-propanoic acid
MW:
169.157
logP:
-3.812
H-acceptors:
6
H-donors:
3
Rotatable bonds:
3
EAATs:
 
EAAT1:
10 µM
EAAT2:
10 µM
EAAT3:
19 µM
EAAT4:
 
EAAT5:
 
Kainate
MW:
213.23
logP:
-0.346
H-acceptors:
5
H-donors:
3
Rotatable bonds:
4
EAATs:
 
EAAT1:
>3000 µM
EAAT2:
59 µM
EAAT3:
>3000 µM
EAAT4:
 
EAAT5: