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N-allyl-exo-THPO
MW:
194.23
logP:
1.64
H-acceptors:
2
H-donors:
2
Rotatable bonds:
3
GATs:
73 µM
GAT1:
 
GAT2:
 
GAT3:
 
GAT4:
 
N-acetyloxyethyl-exo-THPO
MW:
240.26
logP:
0.52
H-acceptors:
3
H-donors:
2
Rotatable bonds:
5
GATs:
 
GAT1:
550 µM
GAT2:
>1000 µM
GAT3:
>1000 µM
GAT4:
>1000 µM
N-acetyloxyethyl-exo-THPO
MW:
240.26
logP:
0.52
H-acceptors:
3
H-donors:
2
Rotatable bonds:
5
GATs:
200 µM
GAT1:
 
GAT2:
 
GAT3:
 
GAT4:
 
N-acetyloxyethyl-exo-THPO
MW:
240.26
logP:
0.52
H-acceptors:
3
H-donors:
2
Rotatable bonds:
5
GATs:
18 µM
GAT1:
 
GAT2:
 
GAT3:
 
GAT4:
 
N-2-hydroxyethyl-exo-THPO
MW:
198.22
logP:
0.29
H-acceptors:
2
H-donors:
3
Rotatable bonds:
3
GATs:
 
GAT1:
>500 µM
GAT2:
>500 µM
GAT3:
>500 µM
GAT4:
>500 µM
N-2-hydroxyethyl-exo-THPO
MW:
198.22
logP:
0.29
H-acceptors:
2
H-donors:
3
Rotatable bonds:
3
GATs:
300 µM
GAT1:
 
GAT2:
 
GAT3:
 
GAT4:
 
N-2-hydroxyethyl-exo-THPO
MW:
198.22
logP:
0.29
H-acceptors:
2
H-donors:
3
Rotatable bonds:
3
GATs:
200 µM
GAT1:
 
GAT2:
 
GAT3:
 
GAT4:
 
N,N-Dimethyl-exo-THPO
MW:
182.22
logP:
1.19
H-acceptors:
2
H-donors:
1
Rotatable bonds:
1
GATs:
>1000 µM
GAT1:
 
GAT2:
 
GAT3:
 
GAT4:
 
N,N-Dimethyl-exo-THPO
MW:
182.22
logP:
1.19
H-acceptors:
2
H-donors:
1
Rotatable bonds:
1
GATs:
>1000 µM
GAT1:
 
GAT2:
 
GAT3:
 
GAT4:
 
Tiagabine
MW:
375.55
logP:
3.417
H-acceptors:
3
H-donors:
1
Rotatable bonds:
6
GATs:
 
GAT1:
0.8 µM
GAT2:
300 µM
GAT3:
>300 µM
GAT4:
800 µM