Wonnemann et al., 2000
4-[2-[5-ethyl-5-[5-[6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-tetrahydropyra
MW:
670.871
logP:
5.009
H-acceptors:
11
H-donors:
4
Rotatable bonds:
10
EAATs:
1.3 µM
EAAT1:
 
EAAT2:
 
EAAT3:
 
EAAT4:
 
EAAT5:
 
Brain region: forebrain
Method: Radioactive labelling
Substrate: no
Comment: The compound inhibits GABA and Glu uptake by affecting the Na+ gradient of the neuronal membrane (Na+ ionophore).
The synaptosomal uptake system used in the experiments can be most closely associated with GAT1 and EAAT3.