Wonnemann et al., 2000
Wonnemann M, Singer A, Muller WE.
Inhibition of synaptosomal uptake of 3H-L-glutamate and 3H-GABA by hyperforin, a major constituent of St. John's Wort: the role of amiloride sensitive sodium conductive pathways.
Neuropsychopharmacology. 2000 Aug;23(2):188-97.
The compound inhibits GABA and Glu uptake by affecting the Na+ gradient of the neuronal membrane (Na+ ionophore).
The synaptosomal uptake system used in the experiments can be most closely associated with GAT1 and EAAT3.